Literature Analysis of Ceftizoxime-induced Hemolytic Anemia / 中国药房

OBJECTIVE:To provide reference for clinical prevention and treatment of ceftizoxime-induced hemolytic anemia by investigating the situation of ceftizoxime-induced hemolytic anemia. METHODS:Using Chinese and English“ceftizoxime”“he-molysis”and other words as key words,related literatures during 1986-2015 were retrieved from CNKI,Wanfang database and PubMed database. Those literatures were analyzed statistically in respects of general information,clinical drug use and manifesta-tion,occurrence time and outcome,etc. The mechanisms of hemolytic anemia were analyzed to put forward prevention and treat-ment measures. RESULTS & CONCLUSIONS:A total of 11 literatures were retrieved,including 4 foreign literatures and 7 domes-tic ones. There were 15 cases in total,including 5 foreign cases and 10 domestic cases. According to the patient’s age,there were 7 cases of infants,4 cases of the elderly,3 cases of middle-aged people and 1 case of youth. The hemolytic anemia often occurred on the 2-7 day(8 cases). Most of the patients were improved after treatment,but there were 3 patients who died. The mechanism of hemolytic anemia mainly included the production of immune complex and non-immunologic protein adsorption. It is suggested to investigate allergic reaction history,pay attention to sensitization test on skin,select suitable drug dosage and avoid drug combina-tion. The patient’s medications should be monitored closely. Once hemolytic anemia occurs,it should be immediately stop using the drug and take appropriate measures as hormone treatment,comprehensive treatment,blood transfusion treatment,to avoid en-dangering the life safety of patients.

Clinical analysis of granulomatous capillary hemangioma of the larynx / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To improve the acknowledgement of clinician on granulomatous capillary hemangioma of the larynx.@*METHOD@#Collect patients in our hospital who were treated with granulomatous capillary hemangioma of the larynx from 2006 to 2011 and the clinical data, treatment and follow-up consequence were retrospectively analyzed.@*RESULT@#There are 10 cases of laryngeal granulomatous capillary. Eight patients with hoarseness as the chief complaint, in the eight patients three cases associated with foreign body sensation in the throat. One patient with hemoptysis as the main performance. The left one patient to hospital because of pharyngeal foreign body sensation associated with blood in the sputum. All were treated with surgery, there are several cases supplemented by CO2 laser treatment, so far no case of postoperative recurrence.@*CONCLUSION@#Granulomatous capillary hemangioma is a benign, vascular proliferation of the skin or mucosa, rather than ture tumor. Recurrence is rare if completely excised. The prognosis is encouraging.

Local recurrence of CO2 laser surgery for patients with early glottic carcinoma: a systematic review and meta-analysis / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#Using meta analysis to assess the local recurrence of CO2 laser surgery for patients with early glottic carcinoma (Tis, T1, N0, M0, T2 N0 M0).@*METHOD@#The Chinese data library (like Wanfang, Weipu, Chinese Periodicals library), PubMed, EMBASE, OVII) and Proquest Medical Library were searched according to including and excluding standard. The reference was screened, quality evaluated and information extracted. Meta analysis was processed by RevMan 5.0. Data including local recurrence after CO2 laser surgery for patients with stage Tis, T1 N0 M0,T2 N0 M0 glottic carcinoma was pulled using appropriate model according to their homogeneity or heterogeneity.@*RESULT@#A total of 27 studies were included in this meta analysis. Group Tis versus T1: P = 0.08, no statistical significance; Group T1a versus T1b: P < 0.01, great statistical significance; Group T1 versus T2: P = 0.09, no statistical significance; Group anterior commissure+ versus anterior commissure: P < 0.01, great statistical significance.@*CONCLUSION@#The local recurrence varies from different kinds of TNM classification of early glottic carcinoma after CO2 laser surgery. There is no statistical significance between group Tis versus T1 and group T1 versus T2. The local recurrence in T1a is lower than in T1b. The local recurrence in group anterior commissure+ is higher than in group anterior commissure+.

Role of CD4+ CD25+ regulatory T cells in peripheral blood from patients with papillary thyroid carcinoma / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the accurate marker to detect regulatory T cells in vivo and also to evaluate the changes of CD4+ CD25+ regulatory T cells in peripheral blood from patients with papillary thyroid carcinoma and clinical significance.@*METHOD@#Forty patients with papillary thyroid carcinoma and 34 patients with thyroid adenoma were included in this study. The proportion of CD4+ D25+ CD127(low/-) regulatory T cells population and CD4+ CD25+ FoxP3- regulatory T cells population was evaluated by flow cytometric analysis.@*RESULT@#Compared with control group, the proportion of CD4+ CD25+ CD127(low/-) regulatory T cells and CD4+ CD25+ FoxP3+ regulatory T cells in PTC group increased significantly (P < 0.05). The proportions of CD4+ CD25+ CD127(low/-) regulatory T cells and CD4+ CD25+ FoxP3+ regulatory T cells were significantly higher between patients with and without cervical lymph node metastasis (P < 0.05), and extraordinarily different among patients with different clinical stages (P < 0.05).@*CONCLUSION@#CD4+ CD25+ CD127(low/-) can be used as an effective membrane marker in identification of CD4+ CD25+ regulatory T cells in stead of CD4+ CD25+ FoxP3+. The CD4+ CD25+ regulatory T cells in the peripheral blood of papillary thyroid carcinoma patients are significantly increased in comparison with that in thyroid adenoma patients. The proportions of Treg of patients with different stages, cervical lymph node metastasis are different. It may be responsible for the happen, development and recurrence of the papillary thyroid carcinoma.

Effect of interferon-gamma on the expression of vascular endothelial growth factor C on Hep-2 laryngeal carcinoma cell lines / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To observe the effect of interferon-gamma on the expression of vascular endothelial growth factor C on Hep-2 laryngeal carcinoma cell lines.@*METHOD@#Hep-2 cell was exposed to interferon-gamma at a concentration (10(3), 10(4), 10(5), 10(6), 10(7) U/L) for 0, 12, 24, 36, 48, 60, 72 h hours. MTT colorimetric assay was used to evaluate the effect of interferon-gamma on Hep-2 cell proliferation after incubation with interferon-gamma. Hep-2 cell was harvested to be detected VEGF-C mRNA levels by realtime polymerase chain reaction (Realtime-PCR) with interferon-gamma (10(6) U/L) for 0, 2, 6, 12, 24, 36, 48, 60, 72 h hours. The VEGF-C protein level in supernatants was determined by enzyme-linked immunosorbent assay (ELISA) and in cytoplasma by immunocytochemical staining and Western blot analysis with the same drug treatment as Realtime-PCR.@*RESULT@#Hep-2 cell was significantly inhibited by IFN-gamma at high concentration. Expression of VEGF-C mRNA and protein levels of Hep-2 cell at 10(6) U/L concentrations of interferon-gamma were lower than that of normal control (P < 0.05) at 48 h.@*CONCLUSION@#IFN-gamma can inhibit the expression of VEGF-C in Hep-2 cell with the level of mRNA and protein.

Management of the sentinel lymph node of papillary thyroid carcinoma in surgery / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the value of sentinel lymph node of papillary thyroid carcinoma exploring and measuring in the metastasis of the cervical lymph node of thyroid carcinoma.@*METHOD@#The sentinel lymph node were investigated by injecting the methylene blue around 25 cases of thyroid tumors. The lymph nodes dyed in blue and obtained from selective lymph node dissection were examined by pathology, respectively. The value of the sentinel lymph nod were evaluated.@*RESULT@#The sentinel lymph nodes dyed in blue were identified in 22 cases which account for 88.0% of all the 25 cases. Nineteen cases of the sentinel lymph node were positive by pathology, of whom 13 cases were verified positive in other area. Six cases were negative.@*CONCLUSION@#It is of great value that sentinel lymph node of thyroid carcinoma can indicate the metastasis of the cervical lymph node of thyroid carcinoma.

A clinical analysis of nebulized Pulmicort respimat around FESS period / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate the recent clinical efficiency of nebulized Pulmicort respimat after FESS.@*METHOD@#Forty-four patients with chronic sinusitis who received FESS, 21 cases were treated with aerosol therapy: Pulmicort respimat , the other 23 cases were treated with Budesonide aqueous nasal spray. All the patients were asked for return at the day 14. Efficacy was evaluated by measurement of nasal symptom scores and sign scores at day 2 and day 14, the biopsy of the membrane on the gap of sinus maxillary were taken to count the eosinophil cell and neutrophil cell in per hundred inflammation cells under microscope and analyze the statistic of the symptom scores, sign scores, efficiency, percentage of the eosinophil cell and the neutrophil cell between two groups at day 14.@*RESULT@#There was no significant differences on the total score between two groups at the day 2, while the therapy group was remarkably lower than that in the control group at the day 14 (P 0.05). The percentage of the eosinophil was no significant differences between two groups (P > 0.05), while the percentage of the neutrophil was lower in the therapy group (P < 0.01).@*CONCLUSION@#Pulmicort respimat and Budesonide are the same type hormones, butPulmicort respimat is a fine granule mixed liquid, with PARI SINUS nasal spray, it can arrive at the whole cavity of the sinus maxillary and be absorbed faster and in a larger space. We consider that nebulized Pulmicort respimat after FESS can relieve the acute inflammation and oedema, it can also reduce the complication of the surgery. The recent clinical efficiency of the Pulmicort respimat is much better than other aqueous nasal spray.